Homologous chromosome segregation

Across TCGA cell cohorts, RNA activity of the Homologous chromosome segregation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGO1, BUB1, and KIF20B, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Homologous chromosome segregation activity versus SGO1 in OESOPHAGUS (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SGO1 →	+1.132	+0.160	.004	.002	3	18
BLOOD_Lymphoma	BUB1 →	+1.013	+0.115	<.001	<.001	3	18
URINARY_TRACT	KIF20B →	+1.086	+0.103	.009	.007	3	17
URINARY_TRACT	MAD2L1 →	+1.115	+0.109	.001	.001	3	17
PANCREAS	TRAIP →	+1.093	+0.113	<.001	<.001	3	17
BLOOD_Myeloma	PSRC1 →	+1.220	+0.071	<.001	.003	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045143 vs SGO1 — OESOPHAGUS

Explore this scatter interactively →