Cellular extravasation

Across TCGA cell cohorts, RNA activity of the Cellular extravasation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCT2, ADIPOR1, and C1QTNF6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular extravasation activity versus CCT2 in LIVER (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CCT2 →	-0.658	-0.274	.009	.002	3	7
BLOOD_Lymphoma	ADIPOR1 →	+1.024	+0.908	<.001	.001	3	7
URINARY_TRACT	C1QTNF6 →	+3.334	+0.543	.002	.002	3	6
LUNG_SCLC	THSD4 →	+1.369	+0.530	<.001	.003	3	6
PANCREAS	PFAS →	-1.183	-0.354	.004	.001	3	6
BLOOD_Leukemia	S100A11 →	+2.463	+0.354	.002	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045123 vs CCT2 — LIVER

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