Protein neddylation

Across TCGA patient cohorts, RNA activity of the Protein neddylation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNRPGP12, UCA1, and TRBV28, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein neddylation activity versus SNRPGP12 in CCRCC (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SNRPGP12 →	-0.750	-0.132	.002	.001	3	4
PDAC	UCA1 →	-0.907	-0.112	.007	.008	3	4
HNSC	TRBV28 →	-0.815	-0.101	.005	.003	3	3
BRCA	TNF →	-0.693	-0.086	<.001	.001	3	3
BRCA	SYNPR-AS1 →	+0.840	+0.133	.004	.001	3	3
GBM	IMPDH1P6 →	-0.223	-0.069	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045116 vs SNRPGP12 — CCRCC

Explore this scatter interactively →