Q-omics provides the consensus-scored UCA1 profile across patient tissues and cancer cell-line models. UCA1 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, UCA1 is differentially expressed in 15, with the highest sampling consensus in KIRC. Additionally, UCA1 RNA expression shows 13,266 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight KIRC, and TGCT as cancer lineages where UCA1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for UCA1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes UCA1 survival associations across molecular data types. UCA1 RNA expression shows survival associations in the most cancer types (21). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible UCA1 RNA expression–survival associations across cancer types. High UCA1 expression shows unfavorable associations in KIRC, PAAD, ACC and ESCA, but favorable associations in LAML and UCS. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for UCA1 RNA expression.
This table summarizes UCA1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for UCA1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. UCA1 shows lower tumor expression in KIRC and KICH and higher tumor expression in COAD, LUAD, UCEC and LUSC. The KIRC box plot shows higher UCA1 RNA expression in normal versus tumor tissue (log2 FC = −1.061, t-test p < 0.001).
This table shows molecular features associated with UCA1 in patient tissues and cancer cell lines. In patient samples, UCA1 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
