Protein neddylation

Across TCGA cell cohorts, RNA activity of the Protein neddylation pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP2R1A, COPS4, and AHCY, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein neddylation activity versus PPP2R1A in URINARY_TRACT (Pearson r = 0.78).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PPP2R1A →	+1.389	+2.370	<.001	<.001	3	20
LUNG_NSCLC_LUSC	COPS4 →	+1.566	+2.125	.001	.003	3	20
LUNG_NSCLC_LUSC	AHCY →	+2.275	+2.653	<.001	<.001	3	19
URINARY_TRACT	ELOB →	+1.621	+2.310	<.001	<.001	3	19
LUNG_NSCLC_LUSC	COPS5 →	+2.187	+2.682	.001	<.001	3	19
LUNG_NSCLC_LUSC	PAICS →	+2.035	+2.445	.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045116 vs PPP2R1A — URINARY_TRACT

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