T-helper 2 cell differentiation

Across TCGA patient cohorts, RNA activity of the T-helper 2 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NTM, PPFIBP1, and ZCCHC24, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T-helper 2 cell differentiation activity versus NTM in LSCC (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NTM →	-0.905	-0.341	<.001	.003	3	5
LSCC	PPFIBP1 →	-0.734	-0.325	<.001	.002	3	5
LSCC	ZCCHC24 →	-0.514	-0.307	<.001	.005	3	5
OV	MMP13 →	-1.556	-0.352	<.001	.004	3	4
LUAD	PDGFB →	-0.519	-0.148	.004	.008	3	4
LUAD	CAP1 →	-0.211	-0.109	.006	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045064 vs NTM — LSCC

Explore this scatter interactively →