Glycerolipid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Glycerolipid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, RPS3A, and SEPTIN4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycerolipid biosynthetic process activity versus RPL5 in GBM (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL5 →	-0.172	-0.022	<.001	.003	2	8
CCRCC	RPS3A →	-0.148	-0.021	<.001	<.001	3	7
GBM	SEPTIN4 →	+0.561	+0.021	<.001	<.001	3	7
LUAD	MKI67_S357 →	-1.284	-0.027	.001	<.001	3	7
GBM	SEPTIN4_S432 →	+0.691	+0.023	.002	.001	3	7
GBM	SYNPO2_S363 →	+1.061	+0.024	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045017 vs RPL5 — GBM

Explore this scatter interactively →