DNA-templated DNA replication maintenance of fidelity

Across TCGA patient cohorts, RNA activity of the DNA-templated DNA replication maintenance of fidelity pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL12_S38, RRM2, and SMC2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA-templated DNA replication maintenance of fidelity activity versus RPL12_S38 in LUAD (Pearson r = 0.75).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL12_S38 →	+1.379	+0.090	<.001	<.001	3	10
LUAD	RRM2 →	+0.989	+0.090	<.001	<.001	3	10
LUAD	SMC2 →	+0.758	+0.102	<.001	<.001	3	10
LUAD	SMC4 →	+0.751	+0.097	<.001	<.001	3	10
LUAD	TOP2A_S1106 →	+1.375	+0.096	<.001	<.001	3	10
LUAD	TOP2A_S1247 →	+1.554	+0.090	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045005 vs RPL12_S38 — LUAD

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