Cell cycle G1/S phase transition

Across TCGA patient cohorts, RNA activity of the Cell cycle G1/S phase transition pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RIF1_S782, SMC4, and CDK2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell cycle G1/S phase transition activity versus RIF1_S782 in GBM (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RIF1_S782 →	+0.548	+0.037	<.001	<.001	3	8
LUAD	SMC4 →	+0.522	+0.039	<.001	<.001	3	8
GBM	CDK2 →	+0.367	+0.030	<.001	<.001	3	8
LUAD	MCM7 →	+0.728	+0.043	<.001	<.001	3	8
LUAD	PTPN2_S304 →	+0.619	+0.035	<.001	<.001	3	8
LUAD	RBBP5_S497 →	+0.865	+0.041	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044843 vs RIF1_S782 — GBM

Explore this scatter interactively →