Mitotic DNA integrity checkpoint signaling

Across TCGA patient cohorts, RNA activity of the Mitotic DNA integrity checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCP110, CPSF6, and DROSHA, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic DNA integrity checkpoint signaling activity versus CCP110 in DLBC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	CCP110 →	+1.559	+0.049	<.001	<.001	3	34
LIHC	CPSF6 →	+0.934	+0.044	<.001	<.001	3	34
DLBC	DROSHA →	+1.037	+0.054	<.001	<.001	3	34
UVM	RBBP6 →	+1.229	+0.037	<.001	<.001	3	34
UVM	IFT81 →	+1.550	+0.037	<.001	<.001	3	34
DLBC	FIGNL1 →	+1.187	+0.041	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044774 vs CCP110 — DLBC

Explore this scatter interactively →