Mitotic DNA integrity checkpoint signaling

Across TCGA cell cohorts, RNA activity of the Mitotic DNA integrity checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPD1L, CYBRD1, and FNDC3B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic DNA integrity checkpoint signaling activity versus GPD1L in BREAST (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GPD1L →	-1.715	-1.174	<.001	<.001	3	4
BREAST	CYBRD1 →	+1.844	+0.892	.004	.002	3	4
BREAST	FNDC3B →	+1.088	+0.935	.002	.002	3	4
STOMACH	MRPS30 →	-0.688	-1.391	<.001	<.001	3	3
BREAST	IFIT2 →	+2.024	+0.996	.006	.005	3	3
LARGE_INTESTINE	IFI44L →	+2.227	+0.876	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044774 vs GPD1L — BREAST

Explore this scatter interactively →