Relaxation of smooth muscle

Across TCGA patient cohorts, RNA activity of the Relaxation of smooth muscle pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KANK2, TLN1, and RCN3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Relaxation of smooth muscle activity versus KANK2 in UCEC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KANK2 →	+0.467	+0.071	<.001	<.001	3	8
UCEC	TLN1 →	+0.423	+0.089	<.001	<.001	3	8
LSCC	RCN3 →	+0.642	+0.092	<.001	<.001	3	7
LSCC	SH3KBP1 →	+0.489	+0.072	<.001	.001	3	7
CCRCC	SYNPO2 →	+0.737	+0.066	<.001	<.001	3	7
CCRCC	SYNPO2_S781 →	+0.796	+0.074	.003	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044557 vs KANK2 — UCEC

Explore this scatter interactively →