Relaxation of smooth muscle

Across TCGA pan-cancer cohorts, RNA activity of the Relaxation of smooth muscle pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 9 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Relaxation of smooth muscle pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LGG and UCS, show the opposite pattern, with higher activity associated with better survival.

KIRC, THYM, and COAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.501	0.677	<.001	54	view →
THYM	DFS	Tertile	All	0.527	0.903	.001	53	view →
COAD	DFS	Median	III,IV	0.563	0.745	.001	49	view →
LGG	DFS	Median	All	0.507	0.312	<.001	37	view →
CESC	OS	Tertile	IV	0.103	0.720	.008	36	view →
STAD	DFS	Tertile	IV	0.171	0.670	.011	26	view →
UCS	OS	Tertile	IV	0.898	0.359	.024	24	view →
UCEC	OS	Tertile	All	0.901	0.950	.017	20	view →
HNSC	DFS	Median	III,IV	0.471	0.176	.007	18	view →
ESCA	DFS	Quartile	III,IV	0.646	0.303	.002	15	view →
TGCT	DFS	Median	All	0.746	0.905	.017	12	view →
DLBC	DFS	Tertile	II,III,IV	0.211	0.892	.025	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0044557–KIRC (OS)

Open the KIRC breakdown →