Motile cilium assembly

Across TCGA patient cohorts, RNA activity of the Motile cilium assembly pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPEPPS, CRTC3-AS1, and ERG28, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Motile cilium assembly activity versus NPEPPS in GBM (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NPEPPS →	+0.277	+0.719	.007	.004	3	4
CCRCC	CRTC3-AS1 →	-0.340	-0.463	<.001	<.001	3	4
COAD	ERG28 →	-0.475	-0.768	<.001	.004	3	3
COAD	RDH11 →	-0.513	-0.878	<.001	<.001	3	3
OV	CFAP69 →	+0.537	+0.683	.002	<.001	3	3
OV	TTC26 →	+0.458	+0.791	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044458 vs NPEPPS — GBM

Explore this scatter interactively →