Protein localization to cytoskeleton

Across TCGA patient cohorts, RNA activity of the Protein localization to cytoskeleton pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A, RRM2, and TOP2A_S1247, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to cytoskeleton activity versus TOP2A in LUAD (Pearson r = 0.63).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TOP2A →	+0.821	+0.048	<.001	<.001	3	9
LUAD	RRM2 →	+0.641	+0.052	<.001	<.001	3	7
LUAD	TOP2A_S1247 →	+0.997	+0.043	<.001	<.001	3	7
GBM	SMC4 →	+0.571	+0.050	<.001	<.001	3	7
LSCC	ACTL6A →	+0.329	+0.049	<.001	<.001	3	7
LUAD	RBBP5_S497 →	+0.900	+0.047	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044380 vs TOP2A — LUAD

Explore this scatter interactively →