Sodium-dependent phosphate transport

Across TCGA cell cohorts, RNA activity of the Sodium-dependent phosphate transport pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMPRSS11B, NRK, and CDK15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMPRSS11B grouped by Sodium-dependent phosphate transport-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMPRSS11B →	-0.267	-0.172	<.001	<.001	3	5
SOFT_TISSUE	NRK →	-0.433	-2.077	.004	<.001	3	4
SOFT_TISSUE	CDK15 →	+0.322	+1.600	.001	.005	3	4
SOFT_TISSUE	MGAM2 →	+0.251	+1.330	<.001	.005	3	4
LUNG_NSCLC_LUSC	ACER3 →	-0.301	-0.273	<.001	<.001	3	4
SOFT_TISSUE	SLC24A1 →	-0.316	-1.282	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMPRSS11B by Sodium-dependent phosphate transport activity — LARGE_INTESTINE

Explore this box plot interactively →