Recognition of apoptotic cell

Across TCGA patient cohorts, RNA activity of the Recognition of apoptotic cell pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGR, LILRA5, and LILRB3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Recognition of apoptotic cell activity versus FGR in BRCA (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FGR →	+0.651	+0.780	<.001	<.001	3	6
BRCA	LILRA5 →	+0.361	+0.480	.005	.003	3	6
BRCA	LILRB3 →	+0.663	+0.681	<.001	<.001	3	6
LSCC	CEACAM3 →	+0.402	+0.724	.007	<.001	2	6
UCEC	LINC02866 →	+0.407	+0.722	.007	.001	3	5
BRCA	NCF1 →	+0.853	+0.736	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043654 vs FGR — BRCA

Explore this scatter interactively →