Dicarboxylic acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Dicarboxylic acid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR12, NOL6, and MTHFD1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dicarboxylic acid biosynthetic process activity versus WDR12 in LSCC (Pearson r = -0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDR12 →	+0.366	+0.053	<.001	<.001	3	9
BRCA	NOL6 →	+0.332	+0.064	<.001	<.001	3	9
HNSC	MTHFD1 →	+0.291	+0.090	<.001	<.001	3	8
LUAD	RRP36_S73 →	+0.707	+0.085	<.001	<.001	3	8
GBM	SUPT16H →	+0.359	+0.064	<.001	<.001	3	8
PDAC	UTP15 →	+0.241	+0.067	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043650 vs WDR12 — LSCC

Explore this scatter interactively →