Dicarboxylic acid metabolic process

Across TCGA cell cohorts, RNA activity of the Dicarboxylic acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCCC2, UQCRC2, and UQCRC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dicarboxylic acid metabolic process activity versus MCCC2 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MCCC2 →	+0.965	+0.328	.001	.002	3	6
STOMACH	UQCRC2 →	+1.068	+0.302	.003	.002	3	5
OVARY	UQCRC1 →	+0.909	+0.255	.004	.001	3	5
BREAST	MTUS1 →	+2.324	+0.205	<.001	.001	3	5
SKIN	IMPA2 →	+1.024	+0.222	.008	.003	3	5
SKIN	COX5A →	+0.843	+0.250	.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043648 vs MCCC2 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →