Tongue morphogenesis

Across TCGA patient cohorts, RNA activity of the Tongue morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SUPT16H_S982, HDAC1_S421, and APBA1_S263, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tongue morphogenesis activity versus SUPT16H_S982 in LUAD (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SUPT16H_S982 →	+1.733	+0.166	<.001	<.001	3	6
LUAD	HDAC1_S421 →	+0.992	+0.204	<.001	<.001	3	6
LUAD	APBA1_S263 →	-0.868	-0.207	<.001	<.001	3	5
PDAC	STAU2_T95 →	+1.402	+0.344	<.001	<.001	3	5
OV	WDFY3_S3339 →	-1.277	-1.445	<.001	<.001	3	5
LSCC	CEP170_S881 →	-0.653	-0.216	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043587 vs SUPT16H_S982 — LUAD

Explore this scatter interactively →