Tongue development

Across TCGA patient cohorts, RNA activity of the Tongue development pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ILF3, TSEN2, and C19orf48, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tongue development activity versus ILF3 in PDAC (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ILF3 →	+0.252	+0.143	.006	.005	3	5
OV	TSEN2 →	+0.299	+0.480	<.001	.005	3	4
LUAD	C19orf48 →	+0.438	+0.114	.005	.003	3	4
PDAC	SNHG12 →	+0.197	+0.129	.003	<.001	3	4
GBM	BCAS1 →	-1.411	-0.155	.003	<.001	3	4
LSCC	CENPV →	+0.742	+0.254	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043586 vs ILF3 — PDAC

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