Negative regulation of insulin-like growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of insulin-like growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLX4, CABIN1, and UNC45A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLX4 grouped by Negative regulation of insulin-like growth factor receptor signaling pathway-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SLX4 →	+0.563	+1.091	.007	.008	3	5
LUNG_NSCLC_LUSC	CABIN1 →	-0.960	-1.399	<.001	<.001	3	4
KIDNEY	UNC45A →	+0.742	+1.996	<.001	<.001	3	4
KIDNEY	ZNF646 →	+0.751	+1.219	.002	<.001	3	4
KIDNEY	FAM234A →	+1.082	+1.252	.007	.004	3	4
LIVER	ANAPC15 →	+1.056	+1.550	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLX4 by Negative regulation of insulin-like growth factor receptor signaling pathway activity — PANCREAS

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