Negative regulation of insulin-like growth factor receptor signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of insulin-like growth factor receptor signaling pathway pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Negative regulation of insulin-like growth factor receptor signaling pathway pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and LGG, show the opposite pattern, with higher activity associated with better survival.

KIRP, BRCA, and UCEC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	0.487	0.837	<.001	130	view →
BRCA	OS	Median	III,IV	0.623	0.449	.001	74	view →
UCEC	DFS	Median	III,IV	0.710	0.870	.001	62	view →
LGG	DFS	Median	All	0.820	0.657	<.001	48	view →
SCLC	OS	Median	II,III,IV	0.799	0.464	.003	39	view →
COAD	OS	Quartile	All	0.604	0.870	.001	38	view →
STAD	DFS	Median	All	0.591	0.805	<.001	32	view →
BLCA	DFS	Tertile	All	0.395	0.632	.007	22	view →
KICH	OS	Median	II,III,IV	0.520	1.000	.008	13	view →
ACC	OS	Median	III,IV	0.597	0.858	.014	13	view →
PRAD	DFS	Tertile	All	0.811	0.919	.001	12	view →
OV	OS	Tertile	IV	0.537	0.771	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0043569–KIRP (DFS)

Open the KIRP breakdown →