Regulation of insulin-like growth factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of insulin-like growth factor receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLS3, MFAP2, and FHL2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of insulin-like growth factor receptor signaling pathway activity versus PLS3 in OV (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PLS3 →	+0.575	+0.049	<.001	<.001	3	7
OV	MFAP2 →	+0.937	+0.062	<.001	<.001	3	7
UCEC	FHL2 →	+0.538	+0.077	<.001	.001	3	6
OV	ECM1 →	+0.582	+0.055	<.001	<.001	3	6
OV	OMD →	+0.970	+0.048	<.001	<.001	3	6
OV	CNN3 →	+0.437	+0.046	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043567 vs PLS3 — OV

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