Regulation of insulin-like growth factor receptor signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of insulin-like growth factor receptor signaling pathway pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 24 member genes.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher Regulation of insulin-like growth factor receptor signaling pathway pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and SCLC, show the opposite pattern, with higher activity associated with better survival.

UCEC, UVM, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.581	0.789	<.001	98	view →
UVM	DFS	Tertile	All	0.812	0.356	.002	63	view →
ACC	OS	Median	All	0.772	0.968	<.001	52	view →
LGG	OS	Median	All	0.369	0.533	<.001	48	view →
KICH	DFS	Median	All	0.549	1.000	.001	40	view →
COAD	OS	Median	All	0.738	0.846	.003	38	view →
SCLC	DFS	Quartile	II,III,IV	0.663	0.226	.001	32	view →
ESCA	DFS	Median	III,IV	0.576	0.342	.003	30	view →
CESC	OS	Quartile	All	0.722	0.875	.010	26	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	18	view →
BRCA	DFS	Tertile	IV	0.773	0.300	.005	16	view →
PAAD	OS	Tertile	All	0.319	0.527	.016	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0043567–UCEC (DFS)

Open the UCEC breakdown →