Regulation of insulin-like growth factor receptor signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of insulin-like growth factor receptor signaling pathway pathway differs between tumor and matched normal tissue in 9 of the 18 cancer types tested.

The strongest signal is observed in thyroid carcinoma (THCA), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KICH and COAD, show the opposite pattern, with lower activity in tumor tissue.

THCA, HNSC, and KIRP show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
THCA	Male	IV	+0.160	<.001	11	view →
HNSC	Male	All	+0.029	.008	6	view →
KIRP	Male	III,IV	+0.042	.013	4	view →
KICH	Male	All	−0.040	.002	4	view →
KIRC	Male	All	+0.031	<.001	4	view →
PAAD	Female	All	+0.084	.042	2	view →
ESCA	All	II,III,IV	+0.060	.013	2	view →
LUSC	All	All	+0.022	.029	2	view →
COAD	All	II,III,IV	−0.025	.031	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 9 strongest of 9 lineages.

GO:0043567–THCA

Open the THCA breakdown →