Regulation of insulin-like growth factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of insulin-like growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGFBP5, MEIS1, and IGFBP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of insulin-like growth factor receptor signaling pathway activity versus IGFBP5 in LSCC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IGFBP5 →	+1.272	+0.211	<.001	<.001	3	5
HNSC	MEIS1 →	+0.675	+0.152	<.001	.002	3	5
LUAD	IGFBP3 →	+0.961	+0.135	<.001	.002	3	5
UCEC	ADSS1 →	+0.582	+0.217	<.001	<.001	3	5
BRCA	ZFPM2 →	+0.525	+0.205	.004	<.001	3	5
CCRCC	EHBP1 →	+0.413	+0.642	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043567 vs IGFBP5 — LSCC

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