Regulation of insulin-like growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of insulin-like growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCAF4, PCNX3, and HAVCR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SCAF4 grouped by Regulation of insulin-like growth factor receptor signaling pathway-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SCAF4 →	+0.418	+0.632	.007	.003	3	5
KIDNEY	PCNX3 →	+1.008	+1.246	<.001	<.001	3	5
LUNG_NSCLC_LUAD	HAVCR2 →	-0.100	-0.761	<.001	<.001	3	4
KIDNEY	PACS2 →	+1.150	+1.571	.002	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	SYDE1 →	-1.304	-1.153	.005	.002	3	4
PANCREAS	ZNF805 →	+0.463	+0.972	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SCAF4 by Regulation of insulin-like growth factor receptor signaling pathway activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →