Regulation of insulin-like growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of insulin-like growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP3K9, KIF9, and RPL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of insulin-like growth factor receptor signaling pathway activity versus MAP3K9 in LUNG_NSCLC_LUSC (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAP3K9 →	+1.111	+1.553	.002	.001	3	5
KIDNEY	KIF9 →	-0.830	-1.662	<.001	<.001	3	5
BREAST	RPL3 →	-0.413	-1.044	.007	.001	3	5
OESOPHAGUS	GNPDA2 →	-1.023	-1.514	.002	<.001	3	4
OVARY	CAPS2 →	-1.030	-1.250	<.001	<.001	3	4
LUNG_NSCLC_LUAD	SLC26A10 →	-1.270	-0.801	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043567 vs MAP3K9 — LUNG_NSCLC_LUSC

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