"Positive regulation of DNA damage response, signal transduction by p53 class mediator"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of DNA damage response, signal transduction by p53 class mediator" pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBLN5, RASGRP2, and C11orf21, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of DNA damage response, signal transduction by p53 class mediator" activity versus FBLN5 in HNSC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FBLN5 →	+0.528	+0.433	.005	.002	3	4
BRCA	RASGRP2 →	+0.757	+0.911	<.001	<.001	3	4
HNSC	C11orf21 →	+0.403	+0.407	.001	<.001	3	3
CCRCC	CPNE5 →	+0.654	+0.878	.001	<.001	3	3
HNSC	SCML4 →	+0.629	+0.510	<.001	<.001	3	3
HNSC	FLI1 →	+0.521	+0.446	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043517 vs FBLN5 — HNSC

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