"Regulation of DNA damage response, signal transduction by p53 class mediator"

Across TCGA patient cohorts, RNA activity of the "Regulation of DNA damage response, signal transduction by p53 class mediator" pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MRC2, CDH11, and DNM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of DNA damage response, signal transduction by p53 class mediator" activity versus MRC2 in BRCA (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MRC2 →	+0.635	+0.036	<.001	<.001	3	6
OV	CDH11 →	+0.612	+0.035	.001	.006	3	6
BRCA	DNM1 →	+0.583	+0.038	<.001	<.001	3	6
BRCA	LRP1 →	+0.668	+0.038	<.001	<.001	3	6
BRCA	CRTAP →	+0.592	+0.031	<.001	<.001	3	6
BRCA	HOOK1 →	-0.309	-0.032	.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043516 vs MRC2 — BRCA

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