"Regulation of DNA damage response, signal transduction by p53 class mediator"

Across TCGA pan-cancer cohorts, RNA activity of the "Regulation of DNA damage response, signal transduction by p53 class mediator" pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 38 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher "Regulation of DNA damage response, signal transduction by p53 class mediator" pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as CESC and SKCM, show the opposite pattern, with higher activity associated with better survival.

KIRC, ACC, and THCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.503	0.695	<.001	106	view →
ACC	OS	Tertile	II,III,IV	0.240	0.841	<.001	80	view →
THCA	OS	Quartile	All	0.766	0.938	<.001	72	view →
UVM	DFS	Quartile	III,IV	0.186	0.832	<.001	68	view →
KIRP	DFS	Median	All	0.784	0.917	<.001	64	view →
LGG	DFS	Tertile	All	0.653	0.801	<.001	41	view →
LIHC	OS	Quartile	All	0.633	0.846	.001	25	view →
MESO	OS	Quartile	All	0.436	0.661	.009	19	view →
LUAD	DFS	Median	All	0.766	0.851	.003	17	view →
CESC	OS	Tertile	All	0.879	0.731	.015	16	view →
SKCM	OS	Median	IV	0.781	0.304	.003	15	view →
STAD	DFS	Median	All	0.618	0.785	.024	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0043516–KIRC (DFS)

Open the KIRC breakdown →