Pigment accumulation

Across TCGA patient cohorts, RNA activity of the Pigment accumulation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are POFUT1, SDF2, and AGPAT5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pigment accumulation activity versus POFUT1 in HNSC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	POFUT1 →	+0.246	+0.053	<.001	<.001	3	6
LSCC	SDF2 →	+0.486	+0.060	<.001	<.001	3	4
LSCC	AGPAT5 →	-0.265	-0.039	.002	.002	3	4
GBM	MYO9B →	+0.256	+0.058	.001	<.001	3	4
GBM	MYO9B_S1290 →	+0.421	+0.054	.002	.002	3	4
GBM	RAB34 →	+0.467	+0.053	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043476 vs POFUT1 — HNSC

Explore this scatter interactively →