Pigment accumulation

Across TCGA cell cohorts, RNA activity of the Pigment accumulation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH18A1, SPDL1, and CNPPD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ALDH18A1 grouped by Pigment accumulation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ALDH18A1 →	+1.091	+1.769	.001	<.001	3	5
BLOOD_Myeloma	SPDL1 →	-0.913	-1.066	.001	.005	2	6
OVARY	CNPPD1 →	-0.394	-1.279	.009	<.001	3	4
OVARY	TGFBR2 →	-1.571	-1.014	.003	<.001	3	4
LUNG_NSCLC_LUSC	APBB2 →	-1.357	-1.145	<.001	.004	3	4
OVARY	MYLK →	-1.739	-1.014	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ALDH18A1 by Pigment accumulation activity — LIVER

Explore this box plot interactively →