Regulation of protein binding

Across TCGA patient cohorts, RNA activity of the Regulation of protein binding pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DEPP1, CEACAM4, and DDX5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein binding activity versus DEPP1 in BRCA (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DEPP1 →	+1.964	+0.350	.002	.009	3	3
COAD	CEACAM4 →	+0.491	+0.112	.003	.002	3	2
COAD	DDX5 →	+0.199	+0.083	.008	.005	3	2
COAD	HNRNPH2 →	+0.246	+0.078	.004	.009	3	2
COAD	F2RL3 →	+0.606	+0.133	<.001	.002	3	2
COAD	PPT1 →	+0.299	+0.099	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043393 vs DEPP1 — BRCA

Explore this scatter interactively →