Regulation of protein binding

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of protein binding pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 143 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Regulation of protein binding pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and SCLC, show the opposite pattern, with higher activity associated with better survival.

KIRP, MESO, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.446	0.790	<.001	112	view →
MESO	DFS	Tertile	All	0.255	0.463	.002	90	view →
UVM	DFS	Median	II,III,IV	0.513	0.881	.001	80	view →
KIRC	OS	Tertile	All	0.528	0.725	<.001	59	view →
SKCM	OS	Tertile	All	0.834	0.730	.001	57	view →
ACC	OS	Tertile	All	0.376	0.767	.006	48	view →
LGG	DFS	Quartile	All	0.704	0.859	<.001	33	view →
LUSC	DFS	Tertile	III,IV	0.280	0.951	<.001	27	view →
LIHC	OS	Tertile	All	0.528	0.742	.003	27	view →
SCLC	DFS	Quartile	All	0.763	0.433	.006	22	view →
ESCA	OS	Median	III,IV	0.596	0.334	.021	19	view →
UCS	DFS	Median	IV	0.981	0.510	.020	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0043393–KIRP (OS)

Open the KIRP breakdown →