Regulation of protein binding

Across TCGA cell cohorts, RNA activity of the Regulation of protein binding pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SWSAP1, KLHL31, and GBP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein binding activity versus SWSAP1 in BLOOD_Lymphoma (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SWSAP1 →	+0.665	+0.254	.002	<.001	3	5
LUNG_SCLC	KLHL31 →	+0.516	+0.238	<.001	<.001	3	4
LARGE_INTESTINE	GBP3 →	-1.511	-0.378	.002	.006	3	4
LARGE_INTESTINE	IL15RA →	-1.312	-0.200	.004	.001	2	5
LUNG_SCLC	SGMS2 →	-1.267	-0.169	.007	.004	3	4
BLOOD_Leukemia	MOB3A →	+1.610	+0.171	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043393 vs SWSAP1 — BLOOD_Lymphoma

Explore this scatter interactively →