Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Across TCGA patient cohorts, RNA activity of the Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEC61A1, TMEM87B, and BAG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway activity versus SEC61A1 in GBM (Pearson r = -0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEC61A1 →	-0.323	-0.058	<.001	<.001	3	4
PDAC	TMEM87B →	-0.520	-0.037	<.001	.002	3	4
PDAC	BAG1 →	+0.197	+0.038	.001	.003	2	5
GBM	HM13 →	-0.399	-0.061	.004	<.001	3	4
PDAC	TMEM214 →	-0.293	-0.030	<.001	.001	3	4
CCRCC	TAPBP →	-0.417	-0.043	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043328 vs SEC61A1 — GBM

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