Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Across TCGA pan-cancer cohorts, RNA activity of the Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 15 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and COAD, show the opposite pattern, with higher activity associated with better survival.

HNSC, KIRP, and COAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.768	0.597	<.001	122	view →
KIRP	DFS	Quartile	II,III,IV	0.334	0.773	<.001	52	view →
COAD	OS	Median	II,III,IV	0.908	0.799	.002	33	view →
SKCM	DFS	Quartile	All	0.337	0.170	.001	33	view →
UCS	DFS	Median	II,III,IV	0.650	0.306	.010	32	view →
UVM	OS	Median	III,IV	0.417	0.898	.005	31	view →
ACC	OS	Quartile	All	0.297	0.749	.001	30	view →
SCLC	DFS	Median	II,III,IV	0.203	0.821	.001	18	view →
DLBC	OS	Median	All	0.656	1.000	.017	16	view →
PAAD	OS	Tertile	All	0.592	0.390	.015	14	view →
GBM	OS	Quartile	All	0.321	0.534	.010	13	view →
CESC	OS	Tertile	IV	0.668	0.295	.025	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0043328–HNSC (DFS)

Open the HNSC breakdown →