Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Across TCGA patient cohorts, RNA activity of the Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CASP9, BBIP1, and DNM1L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway activity versus CASP9 in PDAC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CASP9 →	-0.285	-0.127	.001	.007	3	3
GBM	BBIP1 →	-0.311	-0.170	.004	<.001	3	3
GBM	DNM1L →	-0.294	-0.136	.001	.002	3	3
OV	FASTKD3 →	-0.384	-0.142	.003	.002	3	3
OV	AMER3 →	-0.114	-0.116	.003	.003	3	3
BRCA	PABPN1 →	-0.510	-0.133	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043328 vs CASP9 — PDAC

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