Negative regulation of mast cell degranulation

Across TCGA patient cohorts, RNA activity of the Negative regulation of mast cell degranulation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU5B-4P, SRP14P4, and MTHFD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mast cell degranulation activity versus RNU5B-4P in UCEC (Pearson r = -0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU5B-4P →	+0.724	+0.142	<.001	<.001	3	4
LSCC	SRP14P4 →	-0.589	-0.148	<.001	.002	3	4
CCRCC	MTHFD1 →	-0.348	-0.522	.003	.006	3	4
OV	IRF1 →	+0.847	+0.638	<.001	.005	3	4
LSCC	POLD2 →	-0.415	-0.159	<.001	.001	3	4
LSCC	L3HYPDH →	-0.469	-0.155	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043305 vs RNU5B-4P — UCEC

Explore this scatter interactively →