Negative regulation of mast cell degranulation

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of mast cell degranulation pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher Negative regulation of mast cell degranulation pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and HNSC, show the opposite pattern, with higher activity associated with better survival.

SKCM, UVM, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.938	0.820	<.001	92	view →
UVM	DFS	Tertile	II,III,IV	0.296	0.817	<.001	56	view →
HNSC	DFS	Median	IV	0.786	0.579	<.001	53	view →
LGG	DFS	Median	All	0.665	0.810	<.001	45	view →
KIRC	DFS	Quartile	All	0.701	0.850	.002	44	view →
LAML	DFS	Quartile	All	0.271	0.782	<.001	34	view →
LIHC	DFS	Median	II,III,IV	0.517	0.351	.006	31	view →
ACC	OS	Tertile	II,III,IV	0.719	0.947	.004	24	view →
CESC	DFS	Median	All	0.881	0.770	.003	22	view →
LUAD	OS	Median	II,III,IV	0.716	0.464	<.001	22	view →
ESCA	OS	Median	All	0.659	1.000	.020	12	view →
GBM	OS	Median	All	0.230	0.465	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0043305–SKCM (OS)

Open the SKCM breakdown →