Apical junction assembly

Across TCGA cell cohorts, RNA activity of the Apical junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOAT1, GIPR, and LPCAT4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SOAT1 grouped by Apical junction assembly-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SOAT1 →	+0.918	+0.943	.003	.007	3	4
LUNG_NSCLC_LUAD	GIPR →	-1.088	-0.531	<.001	.002	3	4
LUNG_NSCLC_LUAD	LPCAT4 →	-0.775	-0.732	<.001	.005	3	4
BREAST	OR2B6 →	-0.530	-0.968	<.001	<.001	3	4
SKIN	MT-ND4 →	-0.583	-0.702	.009	.002	3	4
LUNG_NSCLC_LUSC	LYRM9 →	-1.088	-1.351	.004	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SOAT1 by Apical junction assembly activity — OVARY

Explore this box plot interactively →