Response to alkaloid

Across TCGA cell cohorts, RNA activity of the Response to alkaloid pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC149, HOXC8, and TDRP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to alkaloid activity versus CCDC149 in LUNG_NSCLC_LUAD (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CCDC149 →	-0.877	-0.198	.008	.007	3	4
LUNG_NSCLC_LUAD	HOXC8 →	+1.547	+0.213	.001	.001	3	4
BONE	TDRP →	+1.549	+0.180	.003	.009	3	4
CNS	TANGO6 →	+0.568	+0.199	<.001	<.001	3	3
BLOOD_Leukemia	MFAP2 →	-1.190	-0.165	.002	<.001	3	3
STOMACH	PRRC2C →	-1.198	-0.258	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043279 vs CCDC149 — LUNG_NSCLC_LUAD

Explore this scatter interactively →