Anoikis

Across TCGA patient cohorts, RNA activity of the Anoikis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPE, SLC2A8, and BCRP6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anoikis activity versus CPE in HNSC (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CPE →	-1.046	-0.138	<.001	.002	3	4
BRCA	SLC2A8 →	-0.505	-0.192	<.001	<.001	3	4
OV	BCRP6 →	-0.104	-0.189	.008	.009	3	3
OV	SCFD2 →	+0.499	+0.271	.001	.001	3	3
OV	SNORD15B →	+0.939	+0.205	<.001	.002	3	3
OV	MIR4666A →	-0.798	-0.174	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043276 vs CPE — HNSC

Explore this scatter interactively →