Sodium-independent organic anion transport

Across TCGA patient cohorts, RNA activity of the Sodium-independent organic anion transport pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLCO2A1, SLCO2B1, and MYO1F, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sodium-independent organic anion transport activity versus SLCO2A1 in CHOL (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	SLCO2A1 →	+1.851	+0.084	<.001	<.001	3	26
ACC	SLCO2B1 →	+1.962	+0.111	<.001	<.001	3	23
ACC	MYO1F →	+1.206	+0.087	<.001	<.001	3	23
ACC	ITGB2 →	+1.825	+0.081	<.001	<.001	3	23
UVM	TYMP →	+1.478	+0.040	<.001	.002	3	23
ESCA	SLCO4A1 →	+1.511	+0.132	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043252 vs SLCO2A1 — CHOL

Explore this scatter interactively →