Sodium-independent organic anion transport

Across TCGA pan-cancer cohorts, RNA activity of the Sodium-independent organic anion transport pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 15 member genes.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher Sodium-independent organic anion transport pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LIHC and ACC, show the opposite pattern, with higher activity associated with better survival.

LIHC, UVM, and THYM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.779	0.598	<.001	73	view →
UVM	OS	Tertile	All	0.471	0.726	.003	57	view →
THYM	OS	Tertile	All	0.733	1.000	.001	49	view →
ACC	DFS	Quartile	All	0.756	0.311	<.001	43	view →
MESO	OS	Median	II,III,IV	0.296	0.488	.004	35	view →
KICH	DFS	Median	All	1.000	0.713	.001	32	view →
LAML	DFS	Tertile	All	0.256	0.536	.001	28	view →
KIRC	DFS	Quartile	III,IV	0.816	0.684	.006	24	view →
ESCA	DFS	Median	II,III,IV	0.293	1.000	.002	18	view →
PAAD	OS	Median	All	0.294	0.477	.003	18	view →
STAD	OS	Tertile	All	0.388	0.719	.015	12	view →
CHOL	DFS	Median	All	0.648	0.212	.007	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0043252–LIHC (OS)

Open the LIHC breakdown →