Sodium-independent organic anion transport

Across TCGA patient cohorts, RNA activity of the Sodium-independent organic anion transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AMPD3, SDF4, and YBX1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sodium-independent organic anion transport activity versus AMPD3 in GBM (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	AMPD3 →	+0.413	+0.067	<.001	<.001	3	5
COAD	SDF4 →	-0.395	-0.070	<.001	<.001	3	4
CCRCC	YBX1 →	-0.326	-0.120	<.001	<.001	3	4
COAD	EIF4G1 →	-0.139	-0.051	.007	.005	3	4
COAD	H1-0 →	+0.408	+0.051	.004	.008	3	4
LSCC	SPTBN1_S2102 →	+0.308	+0.078	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043252 vs AMPD3 — GBM

Explore this scatter interactively →