Sodium-independent organic anion transport

Across TCGA patient cohorts, RNA activity of the Sodium-independent organic anion transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C7, CD37, and RASAL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sodium-independent organic anion transport activity versus C7 in LSCC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	C7 →	+1.361	+0.192	.001	.001	3	5
GBM	CD37 →	+0.677	+0.818	<.001	<.001	3	4
GBM	RASAL3 →	+0.756	+0.768	<.001	<.001	3	4
GBM	JAK3 →	+0.890	+0.798	.001	<.001	3	4
GBM	ENG →	+0.443	+0.472	<.001	<.001	3	4
GBM	ARHGAP9 →	+0.750	+0.796	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043252 vs C7 — LSCC

Explore this scatter interactively →