Sodium-independent organic anion transport

Across TCGA cell cohorts, RNA activity of the Sodium-independent organic anion transport pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCAT1, CHRNE, and SEC16A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BCAT1 grouped by Sodium-independent organic anion transport-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	BCAT1 →	+1.561	+0.833	.001	.001	3	4
STOMACH	CHRNE →	-0.135	-1.120	<.001	.001	3	3
PANCREAS	SEC16A →	+0.808	+1.326	.001	<.001	3	3
BLOOD_Leukemia	TERF2 →	+0.607	+0.953	.008	.006	3	3
SKIN	TULP4 →	-0.613	-0.938	.005	.005	3	3
BLOOD_Lymphoma	ELP4 →	+0.880	+1.402	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BCAT1 by Sodium-independent organic anion transport activity — SKIN

Explore this box plot interactively →